CALL FOR PAPERS Comparative Genomics Elevated expression of protein biosynthesis genes in liver and muscle of hibernating black bears (Ursus americanus)
نویسندگان
چکیده
Vadim B. Fedorov, Anna V. Goropashnaya, Øivind Tøien, Nathan C. Stewart, Andrew Y. Gracey, Celia Chang, Shizhen Qin, Geo Pertea, John Quackenbush, Louise C. Showe, Michael K. Showe, Bert B. Boyer, and Brian M. Barnes Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska; University of Southern California, Los Angeles, California; Systems Biology Division, The Wistar Institute, Philadelphia, Pennsylvania; Institute for Systems Biology, Seattle, Washington; and Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts
منابع مشابه
Elevated expression of protein biosynthesis genes in liver and muscle of hibernating black bears (Ursus americanus).
We conducted a large-scale gene expression screen using the 3,200 cDNA probe microarray developed specifically for Ursus americanus to detect expression differences in liver and skeletal muscle that occur during winter hibernation compared with animals sampled during summer. The expression of 12 genes, including RNA binding protein motif 3 (Rbm3), that are mostly involved in protein biosynthesi...
متن کاملBone formation is not impaired by hibernation (disuse) in black bears Ursus americanus.
Disuse by bed rest, limb immobilization or space flight causes rapid bone loss by arresting bone formation and accelerating bone resorption. This net bone loss increases the risk of fracture upon remobilization. Bone loss also occurs in hibernating ground squirrels, golden hamsters, and little brown bats by arresting bone formation and accelerating bone resorption. There is some histological ev...
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Disuse typically causes an imbalance in bone formation and bone resorption, leading to losses of cortical and trabecular bone. In contrast, bears maintain balanced intracortical remodeling and prevent cortical bone loss during disuse (hibernation). Trabecular bone, however, is more detrimentally affected than cortical bone in other animal models of disuse. Here we investigated the effects of hi...
متن کاملTrichinella surveillance in black bears (Ursus americanus) from Oregon, USA.
We used serology and muscle digestion to test black bears (Ursus americanus) from western Oregon, USA, for Trichinella. Results indicate black bears in Oregon are not part of a sylvatic cycle for Trichinella, and risk of human exposure to Trichinella larvae from eating black bear meat from Oregon appears low.
متن کاملInsights from the Den: How Hibernating Bears May Help Us Understand and Treat Human Disease.
Hibernating brown bears (Ursus arctos) and black bears (Ursus americanus) spend half of the year in a physically inactive state inside their winter dens without food intake and defecating and no or little urination. Under similar extreme conditions, humans would suffer from loss of lean body mass, heart failure, thrombosis, azotemia, osteoporosis, and more. However, bears exit the den in the sp...
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تاریخ انتشار 2009